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What helps Motilium (therapeutic effects)
Motilium has the following pharmacological effects:
Suppression of vomiting center activity in the brain;
Increase in intensity and duration of contractions of the stomach and duodenum;
Increased pressure in the esophagus;
Acceleration of the evacuation of the food lump from the stomach into the duodenum.

These pharmacological effects provide the therapeutic effect of Motilium, which consists in stopping the symptoms of digestive disorders (flatulence, belching, sensation of heaviness and stomach pain after eating, nausea, vomiting, heartburn, etc.)
(gastritis, peptic ulcer, reflux esophagitis, GERD, gastric hypotonia), as a result of which the food stagnates and does not pass into the duodenum in time.

Motilium improves the contractile activity of the muscles of the stomach,
which leads to a faster evacuation of the food lump in the duodenum. And due to the fact that the food does not stagnate and does not irritate the stomach, people suffer from painful symptoms of dyspepsia (belching, heartburn, flatulence, etc.). That is, Motilium helps to get rid of the symptoms of stomach diseases, in which food stagnates in it.
And since these symptoms can occur in a healthy person, such as overeating, eating fatty or unusual foods, or other violations of a normal balanced diet, Motilium will help, in this case, also to get rid of the unpleasant sensations associated with overcrowding.
Due to increased pressure in the esophagus, Motilium prophylaxes gastroesophageal reflux, reducing heartburn and other symptoms (eructation by acid, etc.), and also contributing to the cure of GERD (gastroesophageal reflux disease). That is, Motilium helps to stop the symptoms of gastroesophageal reflux and GERD.
And due to the suppression of the activity of the emetic center, Motilium is able to eliminate vomiting, provoked by an infectious disease, medication, various chronic pathologies of any organs and systems, as well as functional digestion disorders,
caused by the use of unknown or unusual food and other similar factors.
Motilium – indications for use
Suspension and both types of Motilium tablets are indicated for use in the following identical cases:
1. Coping the following symptoms of gastric hypotension, gastritis, GERD, reflux esophagitis, gastroesophageal reflux,
arising from the delay in food in the stomach and its slow evacuation into the intestine:
Feeling of heaviness, pressure or overcrowding in the stomach after eating;
Pain in the stomach after eating;
Bloating;
Flatulence;
Belching, including sour content;
Nausea;
Vomiting;
Heartburn;
Regurgitation (throwing a fairly large amount of stomach contents into the mouth).
2. Nausea or vomiting caused by infectious diseases, pathologies of any internal organs or functional disorders (for example, inaccuracies in diet, motion sickness, eating too much food at a time, etc.).
3. Nausea and vomiting
, provoked by taking medications, as well as radiotherapy and chemotherapy of tumors.
4. Nausea and vomiting, triggered by taking Levodopa, Bromocriptine, or other preparations of the dopamine agonist group in Parkinsonism.
5. Stopping nausea and vomiting reflex during medical manipulations, for example,
the introduction of a gastric probe, the production of efGDS, etc.
6. Syndrome regurgitation in children.
7. Cyclic vomiting in children.
8. Gastroesophageal reflux in children.
9. Violations of gastric motility in children.
Instructions for use
Consider the rules for using both types of Motilium tablets in one section, since they differ slightly.
And the rules for using Motilium suspension will be discussed in a separate section.
Motilium tablets – instructions for use
Absorbent and coated tablets should be taken 15 to 30 minutes before meals. Also, if necessary, Motilium can be taken before bedtime.

The tablet in the shell is simply swallowed, without cracking and not chewing,
with half a glass of water. A tablet for resorption is put on the tongue and waiting for a few seconds, until it breaks up into small particles. After this, the formed particles are swallowed and, if necessary, washed down with several sips of water. However, if there is no water for some reason,
then absorbable tablets can not be washed down after they have broken up into small pieces in the language and were swallowed.

Tablets in the shell can be extracted from the blister, not observing any special precautions. Care should be taken with absorbable tablets because they are quite fragile.
To avoid breaking and scattering of tablets, it is recommended not to squeeze them out of the blister through the foil, but carefully cut the edge of the cell with scissors. You can also carefully remove the foil from one cell and take out a tablet from it.

To stop the manifestations of dyspepsia (eructations, heartburn, flatulence, a feeling of overcrowding, etc.
) for chronic diseases of the stomach and esophagus for adults and children over 5 years should take 1 tablet 3 times a day before meals, and if necessary before bed. In the absence of effect, children over 12 years and adults can increase the dosage twice, that is, take 2 tablets 3 times a day before meals.
For nausea and vomiting, children over 12 years of age and adults should take 2 tablets 3 to 4 times a day before meals and before bedtime for their cupping. And children 5 to 12 years for the reduction of nausea and vomiting should be given 1 tablet 3 to 4 times a day before meals and at bedtime.
For children from 5 to 12 years, the maximum allowable daily dosage of Motilium is 2.4 mg (1/4 tablet) per 1 kg of body weight, but not more than 80 mg (8 tablets). For adults and adolescents older than 12 years, the maximum allowable daily dosage of Motilium is 80 mg.
Children under 5 years of age are given the drug as a suspension and the dosage is calculated individually by body weight, based on a ratio of 2.5 ml per 10 kg of body weight. Tablets Motilium in children under 5 years old and weighing less than 35 kg are not applied.
Motilium suspension (Motilium for children) – instructions for use
Suspension is intended for use in children under 5 years of age and with a body weight of less than 35 kg. In children of the first year of life, the drug should be used only as directed by a doctor and under constant supervision.

Suspension, as well as tablets should be given to a child 15 to 30 minutes before meals and, if necessary, before going to bed. The amount of the preparation,
Measured with a special syringe, it is necessary to pour into a spoon or in a small container (a glass, a glass, etc.) and give a drink to the child. You can drink the suspension as desired.

The dosage of the suspension for use in relation to various conditions in children is the same and depends only on body weight. Each time the dosage is calculated individually according to the ratio 0
, 25 – 0.5 ml of suspension for every 1 kg of the child’s body weight. The calculated amount of the suspension is given to the child 3 to 4 times a day before meals and, if necessary, before going to bed.

However, since a convenient measuring syringe is supplied with the vial,
on which the variants of the weight of the child are indicated simultaneously in steps of 1 kg and the corresponding amount of suspension in ml, then it is possible not to calculate the dosage for the baby. It is enough to simply use the attached measuring syringe.

The maximum allowable daily dosage of Motilium suspension for children under 5 years is 2.4 ml per 1 kg of body weight,
but not more than 80 mg (80 ml of suspension).

If necessary, the suspension can be taken by adults and adolescents over 12 years in a dosage of 10 – 20 ml 3 to 4 times a day. The maximum permissible daily dose of the suspension for adults and adolescents over 12 years is 80 ml.

Each time before use, shake the vial of the suspension,
then open it according to the following algorithm:
1. Press the cover on top while turning it counter-clockwise;
2. Remove the cover;
3. Take the measuring syringe from the package and lower it into the vial in such a way that its tip goes into the suspension for 1 to 3 cm;
4. Holding the lower ring of the syringe with your fingers,
Raise the piston to the mark that corresponds to the weight of the child;
5. Holding the syringe by the lower ring, remove it from the vial;
6. Squeeze the suspension into a spoon or other container;
7. Rinse the syringe well with warm water after use;
8. Close the vial.
special instructions
Do not use Motilium to stop and prevent postoperative vomiting
.

In renal failure, it is recommended to maximize the intervals between the two subsequent doses of the drug, but do not need to reduce the dosage. However, if a person suffering from kidney failure should take Motilium for a long time, then the entire daily dosage should be divided into 1 – 2 doses, and not 3 – 4.
If the kidney function worsens during the use of the drug, then it is necessary to reduce the dosage of the drug.

For hepatic insufficiency, the drug in any form should be used with caution, constantly monitoring the functions and condition of the liver.

When using Motilium simultaneously with antacids (Rennie, Fosfalugel, Almagel,
Maalox, etc.) and H2-histaminoblockers (Ranitidine, Famotidine, etc.) should be carried out over time. It is optimal to take Motilium before meals, and antacids and H2-histaminblockers – after meals.

Tablets in the shell contain lactose, so they should not be taken by people who are intolerant to milk sugar,
as well as impaired absorption of glucose and galactose. Also, resorption tablets should not be taken by people who have an increased risk of developing hyperphenylalanineemia, due to the content of aspartame in them.

In children under 1 year of age, Motilium may, in rare cases, provoke neurological side effects,
so when using the drug should be strictly adhere to the recommended dosage, without increasing them yourself.
Application in pregnancy and breastfeeding
In pregnancy, Motilium can be taken only if the intended benefit to the mother exceeds possible risks to the fetus.
With breastfeeding, Motilium can not be taken, because in milk the drug is at a concentration of 50% of that in the blood.
Impact on the ability to manage mechanisms
Motilium does not affect the ability of a person to control mechanisms, so against the background of the drug, you can engage in any kind of activity,
requiring high concentration of attention and speed of reactions.
Overdose
Overdose of Motilium is possible and is manifested by the following symptoms:
Drowsiness;
Disorientation;
Agitation (agitation);
Changed consciousness;
Convulsions;
Extrapyramidal reactions (tremor, speech disorders, tics, myoclonus, etc.).
For the treatment of overdose, one-time gastric lavage is performed followed by the sorbent (activated charcoal, Polysorb, Polyphepan, etc.). In the future, if necessary, antihistamines and cholinergic drugs, drugs for the treatment of parkinsonism for the relief of extrapyramidal reactions are used.
Interaction with other drugs
Reduce the severity of the therapeutic effect of Motilium anticholinergics (Aprofen, Atropine, Scopolamine, Dicyclomine, Cyclizine, Benaktizin, etc.), cimetidine and sodium bicarbonate. Enhance the effect of Motilium Fluconazole, Itraconazole, Ketoconazole, Coriconazole, Clarithromycin, Erythromycin, Amprenavir,
Atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, diltiazem, verapamil, amiodarone, aprepitant, nefazodone and telithromycin.

Ketoconazole and Erythromycin with simultaneous application with Motilium cause changes in the ECG, which are normalized after the drugs are withdrawn.
Side Effects of Motilium
Suspension and both types of Motilium tablets can cause the following side effects from different organs and systems:
1. Gastrointestinal tract:
Spasms of the intestine;
Change in activity of ASAT, ALAT and APF;
Diarrhea;
Constipation;
Dry mouth;
Thirst;
Impairment of appetite.
2. The nervous system:
Extrapyramidal syndrome (tics, tremors,
speech disturbance, parkinson-like movements, muscle tone disorders, etc.);
Convulsions;
Drowsiness;
Headache.
3. Mental disorders:
Agitation (excitement);
Nervousness.
4. The immune system:
Anaphylactic reactions (Quincke’s edema, anaphylactic shock, urticaria);
Allergic reactions.
5. Endocrine system:
Increased prolactin levels in the blood;
Galactorrhea (flow of milk from the chest);
Amenorrhea (absence of menstruation);
Gynecomastia.
6. Skin:
Itching;
Rashes.

Extrapyramidal disorders, as a rule, occur in children, but are transient, that is, they disappear on their own after the termination of Motilium administration and do not require special treatment
.
Contraindications for use
Suspension and both versions of Motilium tablets are contraindicated for use in the presence of the following diseases or conditions in a person:
Prolactinoma (a pituitary brain tumor producing prolactin);
Hyperprolactinemia (increased levels of prolactin in the blood);
Simultaneous reception of drugs,
containing as active substances ketoconazole, erythromycin, fluconazole, voriconazole, clarithromycin, amiodarone or telithromycin;
Gastrointestinal bleeding;
Mechanical obstruction of the intestine;
Perforation of any organ of the digestive tract;
Body weight less than 35 kg (for tablets);
Individual sensitivity or intolerance of the drug components;
Pregnancy and lactation.

In children younger than 1 year, Motilium should be used only in the form of a suspension and with care.
Motilium analogues
In the pharmaceutical market, Motilium has analogues and synonyms. Synonyms are the means,
containing the same as Motilium, as active substance domperidone. Analogues are medicines containing other active substances, but having the most similar spectrum of therapeutic effect.

Synonyms Motilium are the following drugs:
Damelyum tablets;
Domet tablets;
Domperidone,
Domperidone Hexal and Domperidone-Teva tablets;
Dostal tablets;
Motigect tablet;
Motilac tablets for resorption and coated;
Mothinorm syrup and tablets;
Motionium tablets;
Pills are chewable and wrapped.

The following preparations are analogues of Motilium:
Aceclydine solution for subcutaneous injection;
Ganaton tablets;
Dimetramid tablets and solution for intramuscular injection;
Itomed tablets;
Ittopa tablets;
Melomide hydrochloride tablets and solution for intravenous and intramuscular injection;
Metoclopramid tablets and solution for intravenous and intramuscular injections;
Metoclopramide-acry tablets;
Metoclopramide-Vial, Metoclopramide-Promed, Metoclopramide-
ESCOR solution for intravenous and intramuscular injections;
Perinorm tablets, solution for oral administration and solution for intravenous and intramuscular injections;
Cerulean tablets and solution for intravenous and intramuscular injection;
Cerucal tablets and solution for intravenous and intramuscular injections.

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